一、个人简介

教授，博士/硕士导师，国家优秀青年基金获得者。现为皇冠体育官网中医药创新研究院/交叉学科研究院副院长。入选中组部“西部之光”青年学者（A类）、中科院青年创新促进会会员、四川省杰出青年科技人才、四川省引进高层次青年人才、云南省“万人计划”等。主要学术兼职包括中国中药协会中药材检测认证技术专业委员会委员、中国生态学学会化学生态专业委员会委员、The Innovation青年编委、Natural Product & Bioprospecting青年编委等。

研究方向：药用植物活性天然产物形成机制与合成生物学

招生专业：中药资源学

联系电话：15087166860

邮箱：liuyan@cdutcm.edu.cn

二、研究领域

长期从事药用植物活性天然产物形成机制与合成生物学研究，主持国家自然科学基金优秀青年基金、NSFC-云南联合基金重点等国家级和省部级科研项目10余项。建立“合成生物学-多组学-中药化学”中药生物合成基因高效发掘体系，解析名贵中药重楼活性成分稀有重楼皂苷连续糖基化生物合成的6个糖基转移酶PpUGT1-6及催化机制，发现重楼皂苷显著抗皮肤癣菌活性与初步作用机制；鉴定佤药/基诺药米团花中二倍半萜生物合成关键酶GFDPS，填补了国际上半个世纪以来对该类重要活性天然产物生物合成途径认识的空白；鉴定首个催化合成最大碳环骨架二倍半萜的新颖萜类合酶LcTPS2，发现产物显著抗炎免疫活性和作用机制；从白族药火把花中鉴定首个高度杂泛植物萜类合酶CcTPS1，为揭示药用植物物质基础多样性和复杂性成因提供科学依据；从滇南常用草药中发现高性能杜松烯合酶基因，实现了重要天然产物杜松烯高效异源合成。建立药用植物生物合成特色元件库，库容元件超过200个。以第一/通讯作者在Angewandte Chemie International Edition、Plant Cell (封面文章)、Acta Pharmaceutica Sinica B、Natural Product Reports等发表SCI论文30余篇，包括中科院一区论文9篇，获省部级自然科学一等奖1项，获授权发明专利4项。

三、代表性成果

1) Yuegui Chen^#, Desen Li^#, Yi Ling^#, Yanchun Liu, Zhili Zuo, Lishe Gan, Shihong Luo, Juan Hua, Dingyuan Chen, Fan Xu, Man Li, Kai Guo, Yan Liu*, Jonathan Gershenzon, Shenghong Li*. A cryptic plant terpene cyclase producing unconventional 18- and 14-membered macrocyclic C₂₅ and C₂₀ terpenoids with immunosuppressive activity. Angewandte Chemie International Edition, 2021, 60: 25468–25476.

2) Yuegui Chen^#, Qin Yan^#, Yunheng Ji, Xue Bai, Desen Li, Rongfang Mu, Kai Guo, Minjie Yang, Yang Tao, Jonathan Gershenzon, Yan Liu*, Shenghong Li*. Unraveling the serial glycosylation in the biosynthesis of steroidalsaponins in the medicinal plant Paris polyphylla and their antifungal action. Acta Pharmaceutica Sinica B, 2023, 13: 4638-4654 (cover article).

3) Yan Liu^#, Shihong Luo^#, Juan Hua, Desen Li, Yi Ling, Qian Luo, Shenghong Li*. Characterization of defensive cadinenes and a novel sesquiterpene synthase responsible for their biosynthesis from the invasive Eupatorium adenophorum. New Phytologist, 2021, 229: 1740–1754.

4) Yan Liu, Shihong Luo, Axel Schmidt, Guodong Wang, Guiling Sun, Marcus Grant, Ce Kuang, Minjie Yang, Shuxi Jing, Chunhuan Li, Bernd Schneider, Jonathan Gershenzon, Shenghong Li*. A geranylfarnesyl diphosphate synthase provides the precursor for sesterterpenoid (C₂₅) formation in the glandular trichomes of the mint species Leucosceptrum canum, Plant Cell, 2016, 28: 804–822 (cover article).

5) Yan Liu, Shuxi Jing, Shihong Luo, Shenghong Li*. Non-volatile natural products in plant glandular trichomes: chemistry, biological activities and biosynthesis. Natural Product Reports, 2019, 36: 626–665.

6) Desen Li, Juan Hua, Shihong Luo, Yanchun Liu, Yuegui Chen, Yi Ling, Kai Guo, Yan Liu*, Shenghong Li*. An extremely promiscuous terpenoid synthase from the Lamiaceae plant Colquhounia coccinea var. mollis catalyzes the formation of sester-/di-/sesqui-/mono-terpenoids. Plant Communications, 2021, 2: 100233 (cover article).

7) Desen Li, Minjie Yang, Rongfang Mu, Shihong Luo, Yuegui Chen, Wenyuan Li, An Wang, Kai Guo, Yan Liu*, Shenghong Li*. Characterization of two chimeric sesterterpene synthases from a fungal symbiont isolated from a sesterterpenoid-producing Lamiaceae plant Leucosceptrum canum. Chinese Chemical Letters, 2023, 34: 107469.

8) Kai Guo^#, Yan Liu^#, Shenghong Li*. The untapped potential of plant sesterterpenoids: chemistry, biological activities and biosynthesis. Natural Product Reports, 2021, 38: 2293–2314.

9) Chunhuan Li^#, Yan Liu^#, Juan Hua, Shihong Luo, Shenghong Li*. Peltate glandular trichomes of Colquhounia seguinii harbor new defensive clerodane diterpenoids. Journal of Integrative Plant Biology, 2014, 56: 928–940.

10) Desen Li, Linlin Shi, Kai Guo, Shihong Luo, Yanchun Liu, Yuegui Chen, Yan Liu*, Shenghong Li*. “A new sesquiterpene synthase catalyzing the formation of (R)-β-bisabolene from medicinal plant Colquhounia coccinea var. mollis and its anti-adipogenic and antibacterial activities”, Phytochemistry, 2023, 211, 113681.