一、个人简介

        敖慧，博士、教授、硕士生导师，中医药创新研究院；学术任职和兼职；中华中医药学会中成药分会副秘书长，主要从事中药配伍理论及中药品种、品质与药效研究；主持国家级课题1项，省部级3项，厅局级5项，主研“973”、国家自然基金等国家级、省部级课题8项。发表学术论文90篇，其中以第一作者或通讯作者发表SCI18篇（最高影响因子11.208，含高被引1篇），合计影响因子100，中文核心30篇，一般10篇；出版教材2部，专著10部，其中副主编3部，编委7部。

二、代表性成果内容简介

        1.人参白术配伍缓解化疗相关性腹泻的增效机制研究

        采用了16SrDNA技术深入探讨人参皂苷和白术挥发油配伍治疗化疗后腹泻的增效机制。16S rDNA扩增子测序的结果表明人参白术有效组分配伍后能够有效抑制5-Fu对小鼠粪便中肠道菌群整体结构的变化。在门水平上，5-Fu显著性升高了Firmicutes的相对丰度，降低了Proteobacteria的相对丰度和Firmicutes/Bacteroidetes（F/B）。在属水平，5-Fu明显增加了与腹泻有关的潜在致病菌Bacteroides、Ruminococcus、Anaerotruncus和Desulfovibrio的相对丰度。单用人参皂苷或白术挥发油不能逆转5-Fu造成的上述肠道菌群结构和门、属丰度的变化。然而，配伍后能够有效地调节肠道菌群不同门的丰度接近正常组，恢复F/B的比例，并能在属的水平上显著抑制5-Fu对上述潜在致病菌的促进作用和单用AMO和PGS对Blautia、Parabacteroides和Lactobacillus丰度变化的副作用。该结果为揭示相须药对的科学内涵提供了依据。

        2.阳春砂仁和绿壳砂仁挥发油比较研究

        本研究采用GC-MS和化学计量学比较研究了阳春砂仁和绿壳砂仁挥发油化学成分。结果表明：顺式橙花苷只存在于绿壳砂仁挥发油中。乙酸龙脑酯和樟脑分别被认为是区分二者最重要的成分。此外，层次聚类分析（HCA）和主成分分析（PCA）成功地区分了两种挥发油的化学成分。此外，偏最小二乘判别分析（PLS-DA）显示乙酸龙脑酯、α-卡地诺、芳樟醇、β-月桂烯、樟脑、D-柠檬烯、萜品烯和冰片等成分可作为鉴别两者的潜在标记物。综上所述，本研究为鉴别两种砂仁提供了一种科学的方法。

三、招生专业

四、代表性成果

[1] Shengmao Li#, Yu Huang#, Lin Liu, Fan Zhang, Hui Ao*, Yingping Luo*. Mechanism of Magnolia Volatile Oil in the Treatment of Acute Pancreatitis Based on GC-MS, Network Pharmacology, and Molecular Docking [J]. Evidence-based complementary and alternative medicine : eCAM, 2023, 2023: 3503888.

[2] Yu Yang, Jiaojiao Wu, Jia Xia, Yan Wan, Jinfeng Xu, Li Zhang, Dong Liu, Lu Chen, Fei Tang, Hui Ao*, Cheng Peng*. Can aloin develop to medicines or healthcare products? [J]. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022, 153: 113421.

[3] Yan Wan, Jia Xia, Jinfeng Xu, Lu Chen, Yu Yang, Jiaojiao Wu, Fei Tang, Hui Ao*, Cheng Peng*. Nuciferine, an active ingredient derived from lotus leaf, lights up the way for the potential treatment of obesity and obesity-related diseases [J]. Pharmacological research, 2022, 175: 106002.

[4] Yan Wan, Dong Liu, Jia Xia, Jinfeng Xu, Li Zhang, Yu Yang, Jiaojiao Wu, Hui Ao*. Ginsenoside CK, rather than Rb1, possesses potential chemopreventive activities in human gastric cancer via regulating PI3K/AKT/NF-κB signal pathway [J]. Frontiers in pharmacology, 2022, 13: 977539.

[5] Jiaojiao Wu, Yu Yang, Yan Wan, Jia Xia, Jinfeng Xu, Li Zhang, Dong Liu, Lu Chen, Fei Tang, Hui Ao*, Cheng Peng*. New insights into the role and mechanisms of ginsenoside Rg1 in the management of Alzheimer's disease [J]. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022, 152: 113207.

[6] Jinfeng Xu, Jia Xia, Yan Wan, Yu Yang, Jiaojiao Wu, Cheng Peng*, Hui Ao*. Vasorelaxant Activities and its Underlying Mechanisms of Magnolia Volatile Oil on Rat Thoracic Aorta Based on Network Pharmacology [J]. Frontiers in pharmacology, 2022, 13: 812716.

[7] Jia Xia, Yan Wan, Jiaojiao Wu, Yu Yang, Jinfeng Xu, Li Zhang, Dong Liu, Lu Chen, Fei Tang, Hui Ao*, Cheng Peng*. Therapeutic potential of dietary flavonoid hyperoside against non-communicable diseases: targeting underlying properties of diseases [J]. Critical reviews in food science and nutrition, 2022, null: 1-31.

[8] Yan Wan, Jing Wang, Jinfeng Xu, Fei Tang, Lu Chen, Yuzhu Tan, Chaolong Rao, Hui Ao*, Cheng Peng*. Panax ginseng and its ginsenosides: potential candidates for the prevention and treatment of chemotherapy-induced side effects [J]. Journal of ginseng research, 2021, 45(6): 617-30.

[9] Jinfeng Xu, Yan Wan, Fei Tang, Lu Chen, Yu Yang, Jia Xia, Jiaojiao Wu, Hui Ao*, Cheng Peng*. Emerging Significance of Ginsenosides as Potentially Reversal Agents of Chemoresistance in Cancer Therapy [J]. Frontiers in pharmacology, 2021, 12: 720474.

[10] Fei Tang#, Yongming Yan#, Hongling Yan, Lixia Wang, Changjiang Hu, Hongliang Wang, Hui Ao*, Cheng Peng*, Yuzhu Tan*. Chuanxiongdiolides R4 and R5, phthalide dimers with a complex polycyclic skeleton from the aerial parts of Ligusticum chuanxiong and their vasodilator activity [J]. Bioorganic chemistry, 2021, 107: 104523.

[11] Fei Tang#, Hongling Yan#, Lixia Wang, Jinfeng Xu, Cheng Peng*, Hui Ao*, Yuzhu Tan*. Review of Natural Resources With Vasodilation: Traditional Medicinal Plants, Natural Products, and Their Mechanism and Clinical Efficacy [J]. Frontiers in pharmacology, 2021, 12: 627458.

[12] Hui Ao#; Wuwen Feng#; Cheng Peng*; Hydroxysafflor Yellow A: A Promising Therapeutic Agent for a Broad Spectrum of Diseases, Evidence-Based Complementary and Alternative Medicine, 2018, 8259280,1-17   

[13] Wuwen Feng#; Hui Ao#; Shijun Yue; Cheng Peng(*), Systems pharmacology reveals the unique mechanism features of Shenzhu Capsule for treatment of ulcerative colitis in comparison with synthetic drugs, Scientific reports, 2018, 8,16160.

[14] Jing Wang#;Wuwen Feng#; Fei Tang; Hui Ao*; Cheng Peng*; Gut microbial transformation, a potential improving factor in the therapeutic activities of four groups of natural compounds isolated from herbal medicines, Fitoterapia, 2019,138,104293.

[15] Jing Wang#;Wuwen Feng#;Shiyang Zhang;Lu Chen;Yongcheng Sheng;Fei Tang;Junlin He;Xin Xu;Hui Ao*;Cheng Peng*;Ameliorative effect of Atractylodes macrocephala essential oil combined with Panax ginseng total saponins on 5-fluorouracil induced diarrhea is associated with gut microbial modulation, Journal of Ethnopharmacology,2019,238, 111887

[16] Jing Wang#; Wuwen Feng#; Shiyang Zhang; Lu Chen, Fei Tang; Yongcheng Sheng;Hui Ao*;Cheng Peng*; Gut microbial modulation in the treatment of chemotherapy-induced diarrhea with Shenzhu Capsule, BMC Complementary and Alternative Medicine, 2019, 19:126.

[17] Hui Ao, Jing Wang, Lu Chen*; Shengmao Li*; Chunmei Dai*; Comparison of Volatile Oil between the Fruits of Amomum villosum Lour. and Amomum villosum Lour. var. xanthioides T. L. Wu et Senjen Based on GC-MS and Chemometric Techniques, Molecules, 2019, 24, 1663

[18] 许金凤,万彦,王晶,唐飞,敖慧*,彭成*.气相色谱-质谱联用技术分析紫苏叶、厚朴共煎煮前后挥发油成分的变化[J].中药新药与临床药理,2020,31(07):848-854.

[19] 张世洋,刘美辰,唐飞,王晶,敖慧*.人参、白术有效组分群对慢性萎缩性胃炎大鼠口腔、肠道菌群的影响[J].中成药,2020,42(01):48-54.

[20] 唐飞,刘美辰,张世洋,王晶,盛永成,冯五文,孙家宜,敖慧*.广藿香、厚朴配伍前后挥发油化学成分及抗菌活性对比研究[J].中药新药与临床药理,2019,30(04):478-483.

[21] 张世洋,刘美辰,唐飞,王晶,敖慧*.人参配伍白术前后皂苷成分及治疗慢性萎缩性胃炎的活性比较[J].中药药理与临床,2019,35(01):117-121.

[22] 黄雅彬,刘红梅,方成鑫,庾洋,陈泓竹,张世洋,李生茂,敖慧*.不同品种川贝母生物碱镇咳、抗炎作用比较[J].中药新药与临床药理,2018,29(01):19-22.

[23] 敖慧.从“同类不可离”解析相须科学内涵[J].中国中医基础医学杂志,2017,23(01):113-115.

[24] 敖慧,叶强*,徐艳文,魏担,豆彩霞,刘红梅,方成鑫.基于GC-MS技术的阳春砂仁煎煮方式的筛选[J].中药新药与临床药理,2016,27(05):705-708.

[25] 敖慧,刘红梅,王江瑞,方成鑫,许莉,郭力,彭成,叶强.不同产地砂仁的挥发油GC-MS分析及重金属残留测定[J].中药新药与临床药理,2016,27(02):250-254.

[26] 李生茂,叶强,敖慧.砂仁挥发油GC-MS指纹图谱与其镇痛作用的关系[J].中成药,2016,38(02):346-350.