一、个人简介

刘菲，博士，博士后，副教授，毕业于清华大学医学部&北京协和医学院药物研究所，世界中医药学会联合会道地药材多维评价专业委员会会员、中华中医药协会会员。长期从事中药药效物质基础的相关研究，先后对藤石松、马尾杉、粗糙马尾杉、龙骨马尾杉、鹿角杜鹃以及姜黄与莪术中的活性成分进行了系统研究，分离获得单体成分400余个，其中新成分100余个，包含5个新颖骨架类结构。主持国家自然科学基金、四川省自然科学基金、博士后基金面上项目、校基金等各级课题5项。课题组探索发现姜黄和莪术活血功效差异与其所含的倍半萜有关，并发现姜黄没药烷型倍半萜类成分具有显著的舒张血管作用，其作用机制与调控PI3K/Akt/eNOS通路有关，为心脑血管疾病新药开发提供了苗头化合物。目前，以第一作者或通讯作者发表SCI论文19篇，包括1区top期刊Organic Letters和2区期刊Biomedicine & Pharmacotherapy、Bioorganic Chemistry、Journal of Natural Products等，且在Tetrahedron中发表论文被选为封面文章。此外，以通讯作者发表中文核心期刊论文10余篇，申请专利2项。

二、代表性成果（可含承担项目、发表论文、论著、获奖等）

主持科研项目情况：

（1）四川省自然科学基金青年科学基金项目，2023NSFSC1773，基于钾离子通道的莪术倍半萜舒张血管作用研究，2023/01-2024/12，10万元，在研，主持

（2）皇冠体育官网“杏林学者”学科人才科研提升计划，QJRC2021008，蓬莪术倍半萜化学成分及其活血功效研究，2021/10-2024/10，18万元，在研，主持

（3）国家自然科学基金青年科学基金项目，81903777，基于倍半萜“异型异效”研究姜黄和莪术活血功效差异的物质基础，2020/01-2022/12，21万元，已结题，主持

（4）中国博士后科学基金面上项目，2019M653362，活血类药姜黄和破血类药莪术功效差异的物质基础研究，2020/01-2021/05，8万元，已结题，主持

（5）皇冠体育官网“杏林学者”学科人才科研提升计划，BSH2018009，蓬莪术抗肿瘤活性成分研究，2018/07-2020/06，6万元，已结题，主持

代表性论文：

(1) Jin-Feng Chen^#, Fei Liu^#, Ming-Ming Qiao, Hong-Zhen Shu, Xiao-Cui Li, Cheng Peng^*, Liang Xiong^*, Vasorelaxant effect of curcubisabolanin A isolated from Curcuma longa through the PI3K/Akt/eNOS signaling pathway, Journal of Ethnopharmacology, 2022, 294: 115332.    

(2) Juan Liu, Ming-Ming Qiao, Cheng Peng, Hong-Zhen Shu, Chun-Wang Meng, Fei Liu^*, Liang Xiong^*, Curcumanes E and F, two rare sesquiterpenoids with a dicyclo[3.3.1]nonane moiety, from Curcuma longa and their vasorelaxant activities, Frontiers in Chemistry, 2022, 10: 995950.

(3) Hong-Zhen Shu, Cheng Peng, Lan Bu, Li Guo, Fei Liu^*, Liang Xiong^*, Bisabolane-type sesquiterpenoids: Structural diversity and biological activity, Phytochemistry, 2021, 192: 112927.    

(4) Fei Liu^#, Jin-Feng Chen^#, Ming-Ming Qiao, Hao-Yu Zhao, Qin-Mei Zhou, Li Guo, Cheng Peng^*, Liang Xiong^*, Seven pairs of new enantiomeric sesquiterpenoids from Curcuma phaeocaulis, Bioorganic Chemistry, 2020, 99: 103820.  

(5) Fei Zhou^#, Fei Liu^#, Juan Liu, Yu-Lin He, Qin-Mei Zhou, Li Guo, Cheng Peng^*, Liang Xiong^*, Stachydrine promotes angiogenesis by regulating the VEGFR2/MEK/ERK and mitochondrial-mediated apoptosis signaling pathways in human umbilical vein endothelial cells, Biomedicine & Pharmacotherapy, 2020, 131: 110724.  

(6) Ming-Ming Qiao^#, Fei Liu^#, Yu Liu, Li Guo, Qin-Mei Zhou, Cheng Peng^*, Liang Xiong^*, Curcumane C and (±)-curcumane D, an unusual seco-cadinane sesquiterpenoid and a pair of unusual nor-bisabolane enantiomers with significant vasorelaxant activity from Curcuma longa, Bioorganic Chemistry, 2019, 92: 103275.

(7) Fei Liu^#, Jin-Feng Chen^#, Yue Wang, Li Guo, Qin-Mei Zhou, Cheng Peng^*, Liang Xiong^*, Cytotoxicity of lanostane-type triterpenoids and ergosteroids isolated from Omphalia lapidescens on MDA-MB-231 and HGC-27 cells, Biomedicine & Pharmacotherapy, 2019, 118: 109273.

(8) Yu Liu^#, Fei Liu^#, Ming-Ming Qiao, Li Guo, Ming-Hua Chen, Cheng Peng^*, Liang Xiong^*, Curcumanes A and B, Two Bicyclic Sesquiterpenoids with Significant Vasorelaxant Activity from Curcuma longa, Organic Letters, 2019, 21(4): 1197-1201.

(9) Fei Liu^#, Ya-Nan Wang^#, Yong Li, Shuang-Gang Ma, Jing Qu, Yun-Bao Liu, Chang-Shan Niu, Zhong-Hai Tang, Yu-Huan Li, Li Li, Shi-Shan Yu^*, Triterpenoids from the twigs and leaves of Rhododendron latoucheae by HPLC‒MS‒SPE‒NMR, Tetrahedron, 2019, 75(2): 296-307.    

(10) Fei Liu^#, Ya-Nan Wang^#, Yong Li, Shuang-Gang Ma, Jing Qu, Yun-Bao Liu, Chang-Shan Niu, Zhong-Hai Tang, Yu-Huan Li, Li Li, Shi-Shan Yu^*, Minor Nortriterpenoids from the Twigs and Leaves of Rhododendron latoucheae, Journal of Natural Products, 2018, 81(8): 1721-1733.