一、个人简介

李丹，博士，副研究员，硕士生导师。

二、研究方向

（1）发现治疗肥胖症、糖尿病和衰老的新型先导化合物

（2）与饮食有关的代谢紊乱的机理研究

（3）中医药对肥胖和衰老相关炎症的机制研究

三、主持的科研项目

（1）国家自然科学基金-青年项目

（2）中国博士后科学基金面上项目和站前特别资助项目

（3）四川省自然科学基金-青年项目

（4）四川省科技创新苗子工程项目

四、代表性论文

1. Guodong Li#, Chung-Nga Ko#, Dan Li#, Chao Yang#, Wanhe Wang, Guan-Jun Yang, Carmelo Di Primo, Vincent Kam Wai Wong, Yaozu Xiang, Ligen Lin*, Dik-Lung Ma*, Chung-Hang Leung*. A small molecule HIF-1α stabilizer that accelerates diabetic wound healing. Nature Communications, 2021, 12: 3363.

2. Junren Chen, Siqi Qin, Shengmeng Liu, Kexin Zhong, Yiqi Jing, Xuan Wu, Fu Peng, Dan Li*, Cheng Peng*. Targeting matrix metalloproteases in diabetic wound healing. Frontiers in Immunology, 2023, online.

3. ChaoYang#, Dan Li#, Shaohong Zang, Yingtang Zhou, Lei Zhang*, Zhangfeng Zhong*. Nanocoating of CsgA protein for enhanced cell adhesion and proliferation. Chinese Chemical Letters, 2023, 34: 107733.

4. Guodong Li#, Dan Li#, Chun Wu#, Shengnan Li, Feng Chen, Peng Li, Chung-Nga Ko, Wanhe Wang, Simon Ming-Yuen Lee, Ligen Lin1*, Dik-Lung Ma*，Chung-Hang Leung*. Homocysteine-targeting compounds as a new treatment strategy for diabetic wounds via inhibition of the histone methyltransferase SET7/9. Experimental and Molecular Medicine, 2022, 54(7):988-998.

5. Ziwei Xing#, Chao Yang#, Junyao He, Yaqian Feng, Xu Li, Cheng Peng*, Dan Li*. Cardioprotective Effects of Aconite in Isoproterenol-Induced Myocardial Infarction in Rats. Oxidative Medicine and Cellular Longevity, 2022: 1090893.

6. Dan Li, Ziwei Xing, Tingting, YuWei Dong, Zhiwei Wang, Cheng Peng*, Chao Yang*. Pogostone attenuates adipose tissue inflammation by regulating the adipocytes-macrophages crosstalk via activating SIRT1.Food & Function, 2022, 13: 11853.

7. Yu Chen#, Fu Peng#, Ziwei Xing, Junren Chen, Cheng Peng*, Dan Li*. Beneficial effects of natural flavonoids on neuroinflammation. Frontiers in Immunology, 2022, 13: 1006434.

8. Dan Li#, Chao Yang#, Jian-Zhong Zhu, Eduardo Lopez, Tian Zhang, Qiang Tong, Cheng Peng*, Ligen Lin*. Berberine remodels adipose tissue to attenuate metabolic disorders by activating sirtuin 3. Acta Pharmacologica Sinica, 2022, 43(5):1285-1298.

9. Nian Chen, Cheng Peng*, Dan Li*. Epigenetic Underpinnings of Inflammation: A Key to Unlock the Tumor Microenvironment in Glioblastoma. Frontiers in Immunology, 2022, 13: 869307.

10. Chao Yang#, Dan Li#, Dehong Teng1, Yueru Zhou3, Lei Zhang3, Zhangfeng Zhong*, Guan-Jun Yang*. Epigenetic Regulation in the Pathogenesis of Rheumatoid Arthritis. Frontiers in Immunology, 2022, 13: 859400.

11. Chao Yang#, Dan Li#, Shaohong Zang, Lei Zhang, Zhangfeng Zhong*, Yingtang Zhou*. Mechanisms of carcinogenic activity triggered by lysine-specific demethylase 1A. Frontiers in Pharmacology, 2022, 13: 955218.

12. Dan Li, Tian Zhang, Jinjian Lu, Cheng Peng*, Ligen Lin*; Natural constituents from food sources as therapeutic agents for obesity and metabolic diseases targeting adipose tissue inflammation.Critical Reviews in Food Science and Nutrition. 2021, 6(12)：1947-1965. 

13. Chao Yang#, Zhen-Zhen Dong#, Jing Zhang, Dehong Teng, Xinzhi Luo, Dan Li*, Yingtang Zhou*. Peptidylarginine deiminases 4 as a promising target in drug discovery. European Journal of Medicinal Chemistry, 2021, 226: 113840.

14. Chao Yang#, Chan-Tat Ng#, Dan Li*, Lei Zhang*. Targeting Indoleamine 2,3-Dioxygenase 1: Fighting Cancers via Dormancy Regulation. Frontiers in Immunology, 2021, 12: 725204.

15. Dan Li, Qianyu Liu, Xiuqiang Lu, Zhengqiu Li, Chunming Wang, Chung-Hang Leung, Yitao Wang, Cheng Peng*, Ligen Lin*. alpha-Mangostin remodels visceral adipose tissue inflammation to ameliorate age-related metabolic disorders in mice. Aging-US, 2019, 11: 11084-11110.

16. Dan Li, Qianyu Liu, Wen Sun, Xiuping Chen, Ying Wang, Yuxiang Sun, Ligen Lin. 1,3,6,7-tetrahydroxy-8-prenylxanthone ameliorates inflammatory responses resulting from the paracrine interaction of adipocytes and macrophages. British Journal of Pharmacology, 2018, 175: 1590-1606.

17. Anqi Wang#, Dan Li#, Shengpeng Wang, Fayang Zhou, Peng Li, Yitao Wang, Ligen Lin. γ-Mangostin, a xanthone from mangosteen, attenuates oxidative injury in liver via NRF2 and SIRT1 induction. Journal of Functional Foods, 2018, 40: 544-553.

18. Zheling Feng#, Dan Li#, Qianyu Liu, Jingxin Liu, Li Huang, Qingwen Zhang, Yitao Wang, Ligen Lin. Anti-inflammatory abietane diterpenoids from the seeds of Podocarpus nagi.Phytochemistry Letters, 2017, 21: 260-263.

19. Li Huang#, Dan Li#, Yunshao Xu, Zheling Feng, Fanchen Meng, Qingwen Zhang, Lishe Gan, Ligen Lin. (). Clausoxamine, an alkaloid possessing a 1,3-oxazine-4-one ring from the seeds of Clausena lansium and the anti-obesity effect of lansiumamide B. RSC Advances, 2017, 7: 46900-46905.

20. Qianyu Liu#, Dan Li#, Anqi Wang, Zhen Dong, Sheng Yin, Qingwen Zhang, Yang Ye, Liangchun Li d, Ligen Lin. Nitric oxide inhibitory xanthones from the pericarps of Garcinia mangostana. Phytochemistry, 2016, 131: 115-123.

21. Dan Li, Cheng Peng, Xiaofang Xie, Yu Mao, Min Li, Zhixing Cao, Danqing Fan. Antidiabetic effect of flavonoids from Malus toringoides (Rehd.) Hughes leaves in diabetic mice and rats. Journal of Ethnopharmacology, 2014, 153: 561-567.